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JAK1 inhibitor

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Catalog No. A13162

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GLPG0634 5mg A13162-5

Regular Price: €190.00

Special Price: €171.00

GLPG0634 10mg A13162-10

Regular Price: €332.50

Special Price: €299.25

GLPG0634 25mg A13162-25

Regular Price: €646.00

Special Price: €581.40

GLPG0634 50mg A13162-50

Regular Price: €1,045.00

Special Price: €940.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.


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Publications citing Adooq Products
GLPG0634  Citations (1)
  • Keisuke Nishimura, .et al. Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice., Arthritis Rheumatol., 2015, Apr;67(4):893-902 PMID: 25545152

Chemical Information

Catalog Num A13162
Actions Inhibitor
M. Wt 410.15
Formula C23H18N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1206101-20-3
Synonyms GLPG 0634, GLPG-0634
SMILES c1cc(n2c(c1)nc(n2)NC(=O)C3CC3)c4ccc(cc4)OCc5ccc(nc5)C#N

Biological Activity

GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.


Solubility (25°C)* In vitro DMSO 0.1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.38 mL 121.91 mL 243.81mL
0.5 mM 4.88 mL 24.38 mL 48.76 mL
1 mM 2.44 mL 12.19 mL 24.38 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 410.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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