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GLPG0634

Catalog No.: A13162

JAK1 inhibitor

GLPG0634

GLPG0634 Chemical Structure

CAS NO. 1206101-20-3

GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.

Availability: In stock

Package Price Qty
5 mg
$200.00
10 mg
$350.00
25 mg
$680.00
50 mg
$1,100.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Keisuke Nishimura, .et al. Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice., Arthritis Rheumatol., 2015, Apr;67(4):893-902 PMID: 25545152

Biological Activity

GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.
Targets
JAK
In vitro DMSO 0.09 mg/mL (0.22 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.38 mL 121.91 mL 243.81 mL
0.5 mM 4.88 mL 24.38 mL 48.76 mL
1 mM 2.44 mL 12.19 mL 24.38 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 410.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13162
Actions Inhibitor
CAS No. 1206101-20-3
Formula C23H18N6O2
M. Wt 410.15
Purity >98%
Synonyms GLPG 0634, GLPG-0634
SMILES c1cc(n2c(c1)nc(n2)NC(=O)C3CC3)c4ccc(cc4)OCc5ccc(nc5)C#N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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