Glycolithocholic acid 3-sulfate disodium functions as a GPR39 agonist, exhibiting EC50 values of 47.9 and 66.8 μM in the absence of Zn2+, and 8 and 8.7 μM in the presence of Zn2+ in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 receptors to promote intracellular calcium signaling without relying on Zn2+ binding sites H17 and H19. Additionally, it demonstrates the ability to inhibit HIV-1 replication in vitro. Glycolithocholic acid 3-sulfate disodium is a valuable tool for investigating HIV infection and gallbladder disease mechanisms.
Glycolithocholic acid 3-sulfate disodium functions as a GPR39 agonist, exhibiting EC50 values of 47.9 and 66.8 μM in the absence of Zn2+, and 8 and 8.7 μM in the presence of Zn2+ in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 receptors to promote intracellular calcium signaling without relying on Zn2+ binding sites H17 and H19. Additionally, it demonstrates the ability to inhibit HIV-1 replication in vitro. Glycolithocholic acid 3-sulfate disodium is a valuable tool for investigating HIV infection and gallbladder disease mechanisms.
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