GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. This compound demonstrates potent anxiolytic-like activity, exhibiting significant dose-dependent effects in various animal models, with an effective oral dosage of 1.6 mg/kg. Notably, GMA-839 has been shown to enhance punished responding in both squirrel monkeys and pigeons. These characteristics position GMA-839 as a valuable tool for research into anxiolytic drug development.
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. This compound demonstrates potent anxiolytic-like activity, exhibiting significant dose-dependent effects in various animal models, with an effective oral dosage of 1.6 mg/kg. Notably, GMA-839 has been shown to enhance punished responding in both squirrel monkeys and pigeons. These characteristics position GMA-839 as a valuable tool for research into anxiolytic drug development.
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