GNE-274

Catalog No.: A85129
Partial ER Agonist
GNE-274 is a selective partial estrogen receptor (ER) agonist that enhances the chromatin accessibility of ER-DNA binding sites, distinguishing it from traditional ER degrader compounds. This compound functions by inhibiting the ligand-binding domain (LBD) of ER, making it a valuable tool in breast cancer research. GNE-274 offers insights into ER signaling pathways and can be instrumental in studies investigating ER-mediated gene regulation and cancer progression.
Grouped product items
Size Price Stock Qty
1mg
$240.00
In stock
5mg
$615.00
In stock
10mg
$1,220.00
In stock
25mg
$2,520.00
In stock
50mg
$3,935.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGNE-274 is a selective partial estrogen receptor (ER) agonist that enhances the chromatin accessibility of ER-DNA binding sites, distinguishing it from traditional ER degrader compounds. This compound functions by inhibiting the ligand-binding domain (LBD) of ER, making it a valuable tool in breast cancer research. GNE-274 offers insights into ER signaling pathways and can be instrumental in studies investigating ER-mediated gene regulation and cancer progression.
Product Information
Catalog NumA85129
FormulaC29H31NO4
Molecular Weight457.56
CAS Number2369048-69-9
SMILESCCCN1CC(C1)COC2=CC=C([C@@H]3OC4=CC=C(C=C4C(C)=C3C5=CC(O)=CC=C5)O)C=C2
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