GNE-317

Catalog No.: A13992

PI3K inhibitor

GNE-317

GNE-317 Chemical Structure

CAS NO. 1394076-92-6

GNE-317 is a potent PI3K inhibitor that can cross the Blood brain barrier; shows potent suppression of the PI3K pathway in the brain of mice with intact BBB.

Availability: In stock

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5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $420.00

Special Price $336.00

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Biological Activity

GNE-317 is a potent PI3K inhibitor that can cross the Blood brain barrier; shows potent suppression of the PI3K pathway in the brain of mice with intact BBB.
Targets
PI3K
In vitro DMSO Warmed: 40 mg/mL (96.5 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.13 mL 120.63 mL 241.27 mL
0.5 mM 4.83 mL 24.13 mL 48.25 mL
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL

*The above data is based on the productmolecular weight 414.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13992
Actions Inhibitor
CAS No. 1394076-92-6
Formula C19H22N6O3S
M. Wt 414.48
Solubility DMSO
Purity >98%
Synonyms GNE317, GNE 317
SMILES COC1(COC1)C2=C(C)C3=C(S2)C(N4CCOCC4)=NC(C5=CN=C(N)N=C5)=N3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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