GNE-493

Catalog No.: A14432

Dual Pan PI3k/mTOR inhibitor

GNE-493

GNE-493 Chemical Structure

CAS NO. 1033735-94-2

GNE-493 is potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor with potential anticancer activity.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $180.00

Special Price $144.00

25 mg

Regular Price: $360.00

Special Price $288.00

50 mg

Regular Price: $650.00

Special Price $520.00

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Biological Activity

GNE-493 is potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor with potential anticancer activity.
In vitro DMSO 63 mg/mL (169.15 mM)
Water Insoluble
Ethanol 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.85 mL 134.25 mL 268.5 mL
0.5 mM 5.37 mL 26.85 mL 53.7 mL
1 mM 2.68 mL 13.42 mL 26.85 mL
5 mM 0.54 mL 2.68 mL 5.37 mL

*The above data is based on the productmolecular weight 372.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14432
Actions Inhibitor
CAS No. 1033735-94-2
Formula C17H20N6O2S
M. Wt 372.44
Purity >98%
Synonyms GNE493, GNE 493
SMILES CC(C)(C1=CC2=C(S1)C(=NC(=N2)C3=CN=C(N=C3)N)N4CCOCC4)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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