Catalog No.: A18672

DLK inhibitor


GNE-8505 Chemical Structure

CAS NO. 1620573-48-9

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).

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Biological Activity

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.84 mL 119.21 mL 238.41 mL
0.5 mM 4.77 mL 23.84 mL 47.68 mL
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL

*The above data is based on the productmolecular weight 419.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18672
Actions Inhibitor
CAS No. 1620573-48-9
Formula C21H24F3N5O
M. Wt 419.44
Purity >98%
Synonyms GNE8505, GNE 8505
SMILES FC(F)(F)C1=CC(C2=NN(C([[email protected]@H]3[[email protected]]4([H])[[email protected]@]3([H])CN(C5COC5)C4)=C2)CC6CC6)=CN=C1N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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