GPR109 receptor agonist-3 is an orally active compound that selectively targets and activates the GPR109 receptor, exhibiting an IC50 of 310 nM. This agonist demonstrates significant antioxidative and cytoprotective properties similar to Lipoic acid. In preclinical studies, GPR109 receptor agonist-3 effectively reduces total cholesterol, triglycerides, and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol in high-fat diet-fed rats. It serves as a valuable tool for investigating the mechanisms underlying atherosclerosis and lipid metabolism.
GPR109 receptor agonist-3 is an orally active compound that selectively targets and activates the GPR109 receptor, exhibiting an IC50 of 310 nM. This agonist demonstrates significant antioxidative and cytoprotective properties similar to Lipoic acid. In preclinical studies, GPR109 receptor agonist-3 effectively reduces total cholesterol, triglycerides, and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol in high-fat diet-fed rats. It serves as a valuable tool for investigating the mechanisms underlying atherosclerosis and lipid metabolism.
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