GPR110 peptide agonist P12 is an agonist targeting the GPR110 receptor. This peptide significantly enhances the initial rate of G protein GTPγS binding stimulated by GPR110, effectively mimicking natural ligands. By inducing dissociation between the receptor's extracellular domain and its seven transmembrane domains, P12 exposes the β-strand-13/stalk region of the 7TM domain, facilitating G protein signaling activation. This compound is valuable for research into developmental disorders and cancers associated with GPR110 pathways.
GPR110 peptide agonist P12 is an agonist targeting the GPR110 receptor. This peptide significantly enhances the initial rate of G protein GTPγS binding stimulated by GPR110, effectively mimicking natural ligands. By inducing dissociation between the receptor's extracellular domain and its seven transmembrane domains, P12 exposes the β-strand-13/stalk region of the 7TM domain, facilitating G protein signaling activation. This compound is valuable for research into developmental disorders and cancers associated with GPR110 pathways.
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