GPR34 receptor antagonist 3 is a selective antagonist of the GPR34 receptor, with an IC50 value of 0.680 μM. This compound effectively inhibits ERK1/2 phosphorylation induced by lysophosphatidylserine in a dose-dependent manner, demonstrating minimal cytotoxicity. GPR34 receptor antagonist 3 is valuable for research into the modulation of sensory signaling pathways and has shown antisensory activity in mouse models of neuropathic pain.
GPR34 receptor antagonist 3 is a selective antagonist of the GPR34 receptor, with an IC50 value of 0.680 μM. This compound effectively inhibits ERK1/2 phosphorylation induced by lysophosphatidylserine in a dose-dependent manner, demonstrating minimal cytotoxicity. GPR34 receptor antagonist 3 is valuable for research into the modulation of sensory signaling pathways and has shown antisensory activity in mouse models of neuropathic pain.
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