GPR52 antagonist-1 is a selective antagonist of the GPR52 receptor, exhibiting an IC50 of 0.63 μM. This compound effectively reduces levels of the mutant huntingtin protein (mHTT) and supports the survival of mouse primary striatal neurons. GPR52 antagonist-1 is important for research applications investigating neurodegenerative disorders, particularly Huntington's disease, and offers insights into the role of GPR52 in neuronal health.
GPR52 antagonist-1 is a selective antagonist of the GPR52 receptor, exhibiting an IC50 of 0.63 μM. This compound effectively reduces levels of the mutant huntingtin protein (mHTT) and supports the survival of mouse primary striatal neurons. GPR52 antagonist-1 is important for research applications investigating neurodegenerative disorders, particularly Huntington's disease, and offers insights into the role of GPR52 in neuronal health.
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