GPR81 agonist 1 is a selective agonist targeting the GPR81 receptor, demonstrating EC50 values of 58 nM for human GPR81 and 50 nM for mouse GPR81. This compound effectively inhibits lipolysis in differentiated 3T3-L1 adipocytes and demonstrates an ability to suppress lipolysis in vivo in mouse models without causing cutaneous flushing. GPR81 agonist 1 exhibits significant selectivity for GPR81 over GPR109a, making it a valuable tool for research into metabolic regulation and adipocyte biology.
GPR81 agonist 1 is a selective agonist targeting the GPR81 receptor, demonstrating EC50 values of 58 nM for human GPR81 and 50 nM for mouse GPR81. This compound effectively inhibits lipolysis in differentiated 3T3-L1 adipocytes and demonstrates an ability to suppress lipolysis in vivo in mouse models without causing cutaneous flushing. GPR81 agonist 1 exhibits significant selectivity for GPR81 over GPR109a, making it a valuable tool for research into metabolic regulation and adipocyte biology.
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