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$0.00 - GuanQun Liu, .et al. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity, Nat Microbiol, 2021, Apr;6(4):467-478 PMID: 33727702
Biological Activity
GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM.
| In vitro | DMSO | 61 mg/mL (200.4 mM) | |
| Water | Insoluble | ||
| Ethanol | 21 mg/mL (68.99 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.85 mL | 164.26 mL | 328.53 mL |
| 0.5 mM | 6.57 mL | 32.85 mL | 65.71 mL |
| 1 mM | 3.29 mL | 16.43 mL | 32.85 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.57 mL |
*The above data is based on the productmolecular weight 304.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18780 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1093070-16-6 |
| Formula | C20H20N2O |
| M. Wt | 304.39 |
| Purity | >98% |
| Synonyms | GRL 0617, GRL-0617 |
| SMILES | O=C(N[[email protected]@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC(N)=CC=C3C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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