GS-829845 is a JAK1 inhibitor that serves as a significant active metabolite of Filgotinib. This compound preferentially inhibits JAK1, exhibiting approximately 10-fold lower potency than its parent compound while demonstrating an extended half-life. GS-829845 is primarily utilized in research related to autoimmune disorders and other inflammatory conditions, contributing to the understanding of JAK pathway modulation in therapeutic applications.
GS-829845 is a JAK1 inhibitor that serves as a significant active metabolite of Filgotinib. This compound preferentially inhibits JAK1, exhibiting approximately 10-fold lower potency than its parent compound while demonstrating an extended half-life. GS-829845 is primarily utilized in research related to autoimmune disorders and other inflammatory conditions, contributing to the understanding of JAK pathway modulation in therapeutic applications.
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