GSK-3685032 is a first-in-class, reversible, non-time-dependent, and noncovalent inhibitor that selectively targets DNA methyltransferase 1 (DNMT1), with an IC₅₀ of 0.036 μM. It induces robust DNA demethylation, leading to transcriptional activation and inhibition of cancer cell growth, making it a promising candidate for epigenetic therapy in oncology.
GSK-3685032 is a first-in-class, reversible, non-time-dependent, and noncovalent inhibitor that selectively targets DNA methyltransferase 1 (DNMT1), with an IC₅₀ of 0.036 μM. It induces robust DNA demethylation, leading to transcriptional activation and inhibition of cancer cell growth, making it a promising candidate for epigenetic therapy in oncology.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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