GSK-3β inhibitor 17 is a potent inhibitor of glycogen synthase kinase 3 beta (GSK-3β). This compound demonstrates a capacity to reduce cisplatin-induced phosphorylation of p65 and the expression of KIM-1 protein and mRNA. Additionally, GSK-3β inhibitor 17 effectively lowers the mRNA levels of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and MCP-1. It exhibits anti-inflammatory properties and holds promise for research into acute kidney injury.
GSK-3β inhibitor 17 is a potent inhibitor of glycogen synthase kinase 3 beta (GSK-3β). This compound demonstrates a capacity to reduce cisplatin-induced phosphorylation of p65 and the expression of KIM-1 protein and mRNA. Additionally, GSK-3β inhibitor 17 effectively lowers the mRNA levels of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and MCP-1. It exhibits anti-inflammatory properties and holds promise for research into acute kidney injury.
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