GSK2126458 (Omipalisib)
Catalog No.: A11035
mTOR/PI3K Inhibitor,
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Research use only. We do not sell to patients.
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Biological Activity
| Description | GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. | |||||
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| Targets |
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| Cell Research |
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Product Information
| Catalog Num | A11035 |
|---|---|
| Formula | C25H17F2N5O3S |
| Molecular Weight | 505.5 |
| CAS Number | 1086062-66-9 |
| SMILES | COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F |
| Synonyms | GSK-2126458 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 96 mg/mL (189.91 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 3 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.78 mL | 98.91 mL | 197.82 mL |
| 0.5 mM | 3.96 mL | 19.78 mL | 39.56 mL |
| 1 mM | 1.98 mL | 9.89 mL | 19.78 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
