GSK2126458 (Omipalisib)

Catalog No.: A11035

mTOR/PI3K Inhibitor,

GSK2126458 (Omipalisib) Chemical Structure

CAS NO. 1086062-66-9

GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.

Availability: In stock

Package Price Qty
2 mg
$80.00
5 mg
$120.00
10 mg
$160.00
50 mg
$420.00
10mM * 1mL in DMSO
$130.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.
Targets
Target Value
p110αki: 0.019nM
p110δki: 0.024nM
p110γki: 0.06nM
p110βki: 0.13nM
mTORC1ki: 0.18nM
mTORC2ki: 0.3nM
In vitro (25°C) DMSO 100 mg/mL (197.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.91 mL 197.82 mL
0.5 mM 3.96 mL 19.78 mL 39.56 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 505.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11035
Actions Inhibitor
M. Wt 505.5
Formula C25H17F2N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1086062-66-9
Synonyms GSK-2126458
SMILES COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F

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