GSK2324 is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of 120 nM. This compound is predominantly utilized in diabetes research, where it plays a pivotal role in the modulation of metabolic processes. Pharmacokinetic studies reveal half-life values of 84 minutes in mice, 170 minutes in rats, 110 minutes in beagle dogs, and 120 minutes in cynomolgus monkeys, indicating its potential for translational studies.
GSK2324 is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of 120 nM. This compound is predominantly utilized in diabetes research, where it plays a pivotal role in the modulation of metabolic processes. Pharmacokinetic studies reveal half-life values of 84 minutes in mice, 170 minutes in rats, 110 minutes in beagle dogs, and 120 minutes in cynomolgus monkeys, indicating its potential for translational studies.
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