GSK2656157

Catalog No.: A13577

PERK Inhibitor

GSK2656157

GSK2656157 Chemical Structure

CAS NO. 1337532-29-2

GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$150.00
50 mg
$250.00
100 mg
$400.00
10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
Targets
PERK (Cell-free assay)
0.9 nM
In vitro DMSO 32 mg/mL (76.83 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.01 mL 120.06 mL 240.12 mL
0.5 mM 4.8 mL 24.01 mL 48.02 mL
1 mM 2.4 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13577
Actions Inhibitor
M. Wt 416.45
Formula C23H21FN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1337532-29-2
Synonyms GSK 2656157
SMILES CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C

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