Home /
Apoptosis /
PERK /
GSK2656157

GSK2656157

Name: GSK2656157
SKU: A13577

Catalog No.: A13577

PERK Inhibitor

Product Citations (1)

GSK2656157

GSK2656157 Chemical Structure

CAS NO. 1337532-29-2

GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.

Availability: In stock

Package	Price	Qty
10 mg	$70.00
25 mg	$150.00
50 mg	$250.00
100 mg	$400.00
10mM * 1mL in DMSO	$75.00

Bulk Inquiry

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Biological Activity

GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.

Targets

PERK (Cell-free assay)
0.9 nM

Solubility *

In vitro	DMSO	32 mg/mL (76.83 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.01 mL	120.06 mL	240.12 mL
0.5 mM	4.8 mL	24.01 mL	48.02 mL
1 mM	2.4 mL	12.01 mL	24.01 mL
5 mM	0.48 mL	2.4 mL	4.8 mL

*The above data is based on the productmolecular weight 416.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13577
Actions	Inhibitor
M. Wt	416.45
Formula	C23H21FN6O
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1337532-29-2
Synonyms	GSK 2656157
SMILES	CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C