GSK2656157

Catalog No.: A13577
PERK Inhibitor
GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
Grouped product items
Product Name Price Stock Qty
GSK2656157 10mg
$70.00
In stock
GSK2656157 25mg
$150.00
In stock
GSK2656157 50mg
$250.00
In stock
GSK2656157 100mg
$400.00
In stock
GSK2656157 10mM * 1mL in DMSO
$75.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's GSK2656157 has been cited by 3 publications
  • Jun Liu, .et al. , Food Chem, 2023, Jun 30;412:135550 PMID: 36706507
  • Cao W, .et al. , J Cell Mol Med, 2019, Aug 23 PMID: 31441588
  • Kosuke Ishikawa, .et al. , Biology Methods and Protocols, 2018, 1-10
  • Biological Activity
    Discription GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nmol/L. It is highly selective for PERK with IC(50) values >100 nmol/L against a panel of 300 kinases.
    Targets
    Target Value
    Product Information
    Catalog Num A13577
    Formula C23H21FN6O
    Molecular Weight 416.45
    CAS Number 1337532-29-2
    SMILES CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=C4C(=NC=N5)N)C
    Synonyms GSK 2656157
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 28 mg/mL (67.23 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% CMC Na 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.01 mL 120.06 mL 240.12 mL
    0.5 mM 4.8 mL 24.01 mL 48.02 mL
    1 mM 2.4 mL 12.01 mL 24.01 mL
    5 mM 0.48 mL 2.4 mL 4.8 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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