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GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.28 mL | 136.41 mL | 272.82 mL |
| 0.5 mM | 5.46 mL | 27.28 mL | 54.56 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.28 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19136 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1629013-22-4 |
| Formula | C20H38N4O2 |
| M. Wt | 366.54 |
| Purity | >98% |
| Synonyms | GSK 3368715, GSK-3368715 |
| SMILES | CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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