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Biological Activity
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.76 mL | 113.78 mL | 227.55 mL |
| 0.5 mM | 4.55 mL | 22.76 mL | 45.51 mL |
| 1 mM | 2.28 mL | 11.38 mL | 22.76 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
*The above data is based on the productmolecular weight 439.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21733 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1628925-77-8 |
| Formula | C20H40Cl2N4O2 |
| M. Wt | 439.46 |
| Purity | >98% |
| Synonyms | EPZ019997 dihydrochloride, EPZ-019997, EPZ 019997; GSK-3368715, GSK 3368715 |
| SMILES | CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C.Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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