GSK621

Catalog No.: A15896

AMPK activator

GSK621

GSK621 Chemical Structure

CAS NO. 1346607-05-3

GSK621 is a potent and selective AMPK agonist.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
25 mg
$550.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Harvey W. Smith, .et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis, Nat Commun, 2019, 10, 2901(2019) PMID: 31263101

Biological Activity

GSK621 is a potent and selective AMPK agonist.
Targets
AMPK
In vitro (25°C) DMSO 84 mg/mL (171.46 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.41 mL 102.06 mL 204.12 mL
0.5 mM 4.08 mL 20.41 mL 40.82 mL
1 mM 2.04 mL 10.21 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL

*The above data is based on the productmolecular weight 489.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15896
Actions Activator
CAS No. 1346607-05-3
Formula C26H20ClN3O5
M. Wt 489.91
Purity >98%
Synonyms GSK-621, GSK 621
SMILES O=C1NC2=C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C2)C(N1C5=CC=CC(OC)=C5)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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