- Khan MI, .et al. Thalidomide attenuates development of m0rphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways, Prog Neuropsychopharmacol Biol Psychiatry, 2018, Mar 2;82:39-48 PMID: 9223784
Biological Activity
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
Targets
Target | Value |
---|---|
Akt1 | IC50: 2nM |
PKCη | IC50: 2nM |
PKCθ | IC50: 2nM |
PrkX | IC50: 5nM |
Akt3 | IC50: 9nM |
Akt2 | IC50: 13nM |
PKCδ | IC50: 14nM |
PKCβ | IC50: 19nM |
PKCε | IC50: 21nM |
PKA | IC50: 24nM |
PKG1β | IC50: 33nM |
In vitro (25°C) | DMSO | 36 mg/mL (84.61 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 2 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.5 mL | 117.51 mL | 235.02 mL |
0.5 mM | 4.7 mL | 23.5 mL | 47 mL |
1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11030 |
---|---|
Actions | Inhibitor |
CAS No. | 937174-76-0 |
Formula | C21H27N7O3 |
M. Wt | 425.5 |
Solubility | DMSO |
Purity | >98% |
Synonyms | GSK-690693 |
SMILES | CCN1C2=C(C(=NC=C2OC[[email protected]]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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