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GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
Targets
| Target | Value |
|---|---|
| Akt1 | IC50: 2nM |
| PKCη | IC50: 2nM |
| PKCθ | IC50: 2nM |
| PrkX | IC50: 5nM |
| Akt3 | IC50: 9nM |
| Akt2 | IC50: 13nM |
| PKCδ | IC50: 14nM |
| PKCβ | IC50: 19nM |
| PKCε | IC50: 21nM |
| PKA | IC50: 24nM |
| PKG1β | IC50: 33nM |
| In vitro (25°C) | DMSO | 39 mg/mL (91.66 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 15% Captisol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.5 mL | 117.51 mL | 235.02 mL |
| 0.5 mM | 4.7 mL | 23.5 mL | 47 mL |
| 1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11030 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 425.5 |
| Formula | C21H27N7O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 937174-76-0 |
| Synonyms | GSK-690693 |
| SMILES | CCN1C2=C(C(=NC=C2OC[[email protected]]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
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