Total item
Cart Subtotal
$0.00 - Khan MI, .et al. Thalidomide attenuates development of m0rphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways, Prog Neuropsychopharmacol Biol Psychiatry, 2018, Mar 2;82:39-48 PMID: 9223784
Biological Activity
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
Targets
| Target | Value |
|---|---|
| Akt1 | IC50: 2nM |
| PKCη | IC50: 2nM |
| PKCθ | IC50: 2nM |
| PrkX | IC50: 5nM |
| Akt3 | IC50: 9nM |
| Akt2 | IC50: 13nM |
| PKCδ | IC50: 14nM |
| PKCβ | IC50: 19nM |
| PKCε | IC50: 21nM |
| PKA | IC50: 24nM |
| PKG1β | IC50: 33nM |
| In vitro (25°C) | DMSO | 36 mg/mL (84.61 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.5 mL | 117.51 mL | 235.02 mL |
| 0.5 mM | 4.7 mL | 23.5 mL | 47 mL |
| 1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11030 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 937174-76-0 |
| Formula | C21H27N7O3 |
| M. Wt | 425.5 |
| Purity | >98% |
| Synonyms | GSK-690693 |
| SMILES | CCN1C2=C(C(=NC=C2OC[[email protected]]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
MK-2206 2HCl
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
TIC10 isomer
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, s…
A-674563
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respe…
GSK2141795 (Uprosertib, GSK795)
Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tum…
Deguelin
Deguelin is a natural product that displays profound antiproliferative activity.
PHT-427
PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
AT7867 2HCl
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, resp…
GDC-0068 (Ipatasertib, RG-7440)
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in…
Keywords:buy GSK690693 | GSK690693 Supplier | purchase | cost | manufacturer | order | distributor | buy 937174-76-0| 937174-76-0 Supplier | purchase 937174-76-0 | 937174-76-0 cost | 937174-76-0 manufacturer | order 937174-76-0 | 937174-76-0 distributor
Adooq Quality Guarantee
We promise all products perform as described.