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$0.00 - Guohao Wang, .et al. A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis, Nat Commun, 2021, Sep 30;12(1):5733 PMID: 34593794
Biological Activity
W4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).
| In vitro | DMSO | Insoluble | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.32 mL | 86.58 mL | 173.16 mL |
| 0.5 mM | 3.46 mL | 17.32 mL | 34.63 mL |
| 1 mM | 1.73 mL | 8.66 mL | 17.32 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.46 mL |
*The above data is based on the productmolecular weight 577.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11974 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 6823-69-4 |
| Formula | C30H28N6O2.2HCl |
| M. Wt | 577.5 |
| Purity | >90% |
| Synonyms | GW-4869, GW4869 |
| SMILES | C1NC(=NC1)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(C=C3)/C=C/C(=O)NC4=CC=C(C=C4)C5=NCCN5.O.Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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