GW 4869

Catalog No.: A11974

N-SMase inhibitor

GW 4869

GW 4869 Chemical Structure

CAS NO. 6823-69-4

W4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

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  • Guohao Wang, .et al. A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis, Nat Commun, 2021, Sep 30;12(1):5733 PMID: 34593794

Biological Activity

W4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).
In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.32 mL 86.58 mL 173.16 mL
0.5 mM 3.46 mL 17.32 mL 34.63 mL
1 mM 1.73 mL 8.66 mL 17.32 mL
5 mM 0.35 mL 1.73 mL 3.46 mL

*The above data is based on the productmolecular weight 577.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11974
Actions Inhibitor
CAS No. 6823-69-4
Formula C30H28N6O2.2HCl
M. Wt 577.5
Purity >90%
Synonyms GW-4869, GW4869
SMILES C1NC(=NC1)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(C=C3)/C=C/C(=O)NC4=CC=C(C=C4)C5=NCCN5.O.Cl.Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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