GW 4869

Catalog No.: A11974
N-SMase inhibitor

GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

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GW 4869 5mg
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GW 4869 10mg
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GW 4869 50mg
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's GW 4869 has been cited by 1 publications
  • Guohao Wang, .et al. , Nat Commun, 2021, Sep 30;12(1):5733 PMID: 34593794
  • Biological Activity

    GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

    Product Information
    Catalog Num A11974
    Formula C30H28N6O2.2HCl
    Molecular Weight 577.5
    CAS Number 6823-69-4
    SMILES C1NC(=NC1)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(C=C3)/C=C/C(=O)NC4=CC=C(C=C4)C5=NCCN5.O.Cl.Cl
    Synonyms GW-4869, GW4869

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro DMSO Insoluble
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 17.32 mL 86.58 mL 173.16 mL
    0.5 mM 3.46 mL 17.32 mL 34.63 mL
    1 mM 1.73 mL 8.66 mL 17.32 mL
    5 mM 0.35 mL 1.73 mL 3.46 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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