GW 4869
GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).
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Adooq Products cited in reputable paper
Adooq's GW 4869 has been cited by 2 publications
- Salar Ghaffari Gabaran, .et al. , Biochem Pharmacol, 2025, Sep:239:117019 PMID: 40499840
- Guohao Wang, .et al. , Nat Commun, 2021, Sep 30;12(1):5733 PMID: 34593794
Biological Activity
| Description | GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). |
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Product Information
| Catalog Num | A11974 |
|---|---|
| Formula | C30H28N6O2.2HCl |
| Molecular Weight | 577.5 |
| CAS Number | 6823-69-4 |
| SMILES | C1NC(=NC1)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(C=C3)/C=C/C(=O)NC4=CC=C(C=C4)C5=NCCN5.O.Cl.Cl |
| Synonyms | GW-4869, GW4869 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro | DMSO | Insoluble | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.32 mL | 86.58 mL | 173.16 mL |
| 0.5 mM | 3.46 mL | 17.32 mL | 34.63 mL |
| 1 mM | 1.73 mL | 8.66 mL | 17.32 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.46 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
