GW559090 is a selective α4 integrin antagonist that competitively inhibits α4β1 with a Kd of 0.19 nM. It effectively disrupts the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 nM and 8.04 nM, respectively. Additionally, GW559090 inhibits the α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) interaction (IC50 = 23 nM). This compound has potential applications in research focused on inflammatory conditions such as Sjögren's syndrome and related dry eye disorders.
GW559090 is a selective α4 integrin antagonist that competitively inhibits α4β1 with a Kd of 0.19 nM. It effectively disrupts the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 nM and 8.04 nM, respectively. Additionally, GW559090 inhibits the α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) interaction (IC50 = 23 nM). This compound has potential applications in research focused on inflammatory conditions such as Sjögren's syndrome and related dry eye disorders.
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