GW788388

Catalog No.: A11083

TGF-beta/Smad inhibitor

GW788388

GW788388 Chemical Structure

CAS NO. 452342-67-5

GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $38.00

Special Price $30.40

10 mg

Regular Price: $60.00

Special Price $48.00

50 mg

Regular Price: $200.00

Special Price $160.00

100 mg

Regular Price: $360.00

Special Price $288.00

10mM * 1mL in DMSO
$91.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).
Targets
ALK5 (Cell-free assay)
18 nM
In vitro (25°C) DMSO 15 mg/mL (35.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02 mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11083
Actions Inhibitor
M. Wt 425.5
Formula C25H23N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 452342-67-5
Synonyms GW-788388
SMILES C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5

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