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Biological Activity
GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.67 mL | 103.35 mL | 206.69 mL |
| 0.5 mM | 4.13 mL | 20.67 mL | 41.34 mL |
| 1 mM | 2.07 mL | 10.33 mL | 20.67 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.13 mL |
*The above data is based on the productmolecular weight 483.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21204 |
|---|---|
| Actions | Modulator |
| CAS No. | 309712-55-8 |
| Formula | C20H27Cl3F2N4O |
| M. Wt | 483.81 |
| Purity | >98% |
| Synonyms | GW 791343, GW-791343 |
| SMILES | O=C(NC1=CC(CN2CCNCC2)=CC=C1C)CNC3=CC=C(F)C(F)=C3.[H]Cl.[H]Cl.[H]Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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