GW9508

Catalog No.: A11965

GPR40 Inhibitor

GW9508

GW9508 Chemical Structure

CAS NO. 885101-89-3

GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.

Availability: In stock

Package Price Qty
10 mg
$50.00
25 mg
$100.00
50 mg
$160.00
10mM * 1mL in DMSO
$94.00
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Biological Activity

GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.
Targets
GPR40 GPR120
7.32(pEC50)5.46(pEC50)
In vitro DMSO 69 mg/mL (198.61 mM)
Water <1 mg/mL (<1 mM)
Ethanol 69 mg/mL (198.61 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.79 mL 143.93 mL 287.85 mL
0.5 mM 5.76 mL 28.79 mL 57.57 mL
1 mM 2.88 mL 14.39 mL 28.79 mL
5 mM 0.58 mL 2.88 mL 5.76 mL

*The above data is based on the productmolecular weight 347.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11965
Actions Inhibitor
M. Wt 347.4
Formula C22H21NO3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 885101-89-3
Synonyms GW 9508, GW-9508
SMILES C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O

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