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GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.
Targets
| GPR40 | GPR120 | |||
| 7.32(pEC50) | 5.46(pEC50) |
| In vitro | DMSO | 69 mg/mL (198.61 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 69 mg/mL (198.61 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.79 mL | 143.93 mL | 287.85 mL |
| 0.5 mM | 5.76 mL | 28.79 mL | 57.57 mL |
| 1 mM | 2.88 mL | 14.39 mL | 28.79 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
*The above data is based on the productmolecular weight 347.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11965 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 347.4 |
| Formula | C22H21NO3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 885101-89-3 |
| Synonyms | GW 9508, GW-9508 |
| SMILES | C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O |
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