H3R Antagonist 6 is a potent antagonist of the Histamine receptor 3 (H3R), exhibiting an IC50 of 5.6 nM. This compound, when labeled with 18F, demonstrates high radiochemical yield and molar activity, alongside moderate brain uptake, albeit with some off-target binding to the Sigma-1 receptor. H3R Antagonist 6 serves as a valuable PET radioligand for positron emission tomography imaging, facilitating research into central nervous system (CNS) disorders.
H3R Antagonist 6 is a potent antagonist of the Histamine receptor 3 (H3R), exhibiting an IC50 of 5.6 nM. This compound, when labeled with 18F, demonstrates high radiochemical yield and molar activity, alongside moderate brain uptake, albeit with some off-target binding to the Sigma-1 receptor. H3R Antagonist 6 serves as a valuable PET radioligand for positron emission tomography imaging, facilitating research into central nervous system (CNS) disorders.
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