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- Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485
Biological Activity
Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.
Targets
| prolyl-tRNA synthetase | ||||
| 18.3nM(Ki) |
| In vitro | DMSO | 17 mg/mL (40.99 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.11 mL | 120.57 mL | 241.15 mL |
| 0.5 mM | 4.82 mL | 24.11 mL | 48.23 mL |
| 1 mM | 2.41 mL | 12.06 mL | 24.11 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
*The above data is based on the productmolecular weight 414.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12441 |
|---|---|
| CAS No. | 55837-20-2 |
| Formula | C16H17BrClN3O3 |
| M. Wt | 414.68 |
| Purity | >98% |
| Synonyms | Tempostatin; RU 19110 |
| SMILES | C1C[[email protected]]([[email protected]@H](NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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