HIV-1 inhibitor-21 is a potent non-nucleoside reverse transcriptase inhibitor targeting the HIV-1 reverse transcriptase enzyme, achieving an IC50 of 0.55 μM. This compound exhibits significant antiretroviral activity against both HIV-1 wild-type and K103N strains, with EC50 values of 12.7 nM and 10.4 nM, respectively. Notably, HIV-1 inhibitor-21 demonstrates low cytotoxicity, with a CC50 of 10.2 μM in MT-4 cells, making it a valuable candidate for HIV research and therapeutic exploration.
HIV-1 inhibitor-21 is a potent non-nucleoside reverse transcriptase inhibitor targeting the HIV-1 reverse transcriptase enzyme, achieving an IC50 of 0.55 μM. This compound exhibits significant antiretroviral activity against both HIV-1 wild-type and K103N strains, with EC50 values of 12.7 nM and 10.4 nM, respectively. Notably, HIV-1 inhibitor-21 demonstrates low cytotoxicity, with a CC50 of 10.2 μM in MT-4 cells, making it a valuable candidate for HIV research and therapeutic exploration.
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