HIV-1 inhibitor-24 (compound S-12a) is a potent inhibitor of HIV-1 reverse transcriptase, demonstrating an IC50 value of 9.5 nM. This compound exhibits strong antiretroviral activity against wild-type HIV-1, with an EC50 of 1.6 nM, while maintaining a low cytotoxic profile (CC50 of 9.07 μM in MT-4 cells). In vivo studies indicate that HIV-1 inhibitor-24 is well tolerated at doses of 2 g/kg in mice and shows favorable cardiovascular safety, making it a valuable tool for HIV-1 research and potential therapeutic development.
HIV-1 inhibitor-24 (compound S-12a) is a potent inhibitor of HIV-1 reverse transcriptase, demonstrating an IC50 value of 9.5 nM. This compound exhibits strong antiretroviral activity against wild-type HIV-1, with an EC50 of 1.6 nM, while maintaining a low cytotoxic profile (CC50 of 9.07 μM in MT-4 cells). In vivo studies indicate that HIV-1 inhibitor-24 is well tolerated at doses of 2 g/kg in mice and shows favorable cardiovascular safety, making it a valuable tool for HIV-1 research and potential therapeutic development.
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