HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an IC50 value of 0.1061 μM. This compound demonstrates significant antiretroviral activity against wild-type HIV-1, with an EC50 of 13.6 nM, while maintaining low cytotoxicity (CC50 of 33.13 μM) in MT-4 cells. Additionally, HIV-1 inhibitor-25 shows inhibitory effects on various HIV-1 mutant strains, presenting EC50 values ranging from 0.1961 to 5.8136 μM. This reagent is valuable for research focused on HIV/AIDS therapies.
HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an IC50 value of 0.1061 μM. This compound demonstrates significant antiretroviral activity against wild-type HIV-1, with an EC50 of 13.6 nM, while maintaining low cytotoxicity (CC50 of 33.13 μM) in MT-4 cells. Additionally, HIV-1 inhibitor-25 shows inhibitory effects on various HIV-1 mutant strains, presenting EC50 values ranging from 0.1961 to 5.8136 μM. This reagent is valuable for research focused on HIV/AIDS therapies.
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