hMAO-B-IN-2 is a potent and selective inhibitor of human monoamine oxidase B (hMAO-B), exhibiting a competitive reversible mechanism with an IC50 of 4 nM. This compound is characterized by its ability to penetrate the blood-brain barrier and demonstrates low toxicity alongside significant neuroprotective effects in SH-SY5Y neuroblastoma cells. hMAO-B-IN-2 is suitable for research applications related to Alzheimer's disease and also serves as a versatile click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
hMAO-B-IN-2 is a potent and selective inhibitor of human monoamine oxidase B (hMAO-B), exhibiting a competitive reversible mechanism with an IC50 of 4 nM. This compound is characterized by its ability to penetrate the blood-brain barrier and demonstrates low toxicity alongside significant neuroprotective effects in SH-SY5Y neuroblastoma cells. hMAO-B-IN-2 is suitable for research applications related to Alzheimer's disease and also serves as a versatile click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
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