hMCH-1R antagonist 1 is a selective antagonist of the human melanin-concentrating hormone receptor 1 (hMCHR1) with a binding affinity characterized by a KB value of 3.6 nM. This compound demonstrates effective inhibition of hMCHR1 and hMCHR2, with IC50 values of 65 nM and 49 nM, respectively. hMCH-1R antagonist 1 is suitable for investigations into metabolic pathways and the role of melanin-concentrating hormone in various physiological processes.
hMCH-1R antagonist 1 is a selective antagonist of the human melanin-concentrating hormone receptor 1 (hMCHR1) with a binding affinity characterized by a KB value of 3.6 nM. This compound demonstrates effective inhibition of hMCHR1 and hMCHR2, with IC50 values of 65 nM and 49 nM, respectively. hMCH-1R antagonist 1 is suitable for investigations into metabolic pathways and the role of melanin-concentrating hormone in various physiological processes.
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