HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, HS-PEG11-CH2CH2N3 can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities containing DBCO or BCN functional groups. This versatility makes it a valuable tool for advancing proteomic research and targeted protein degradation studies.
HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, HS-PEG11-CH2CH2N3 can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities containing DBCO or BCN functional groups. This versatility makes it a valuable tool for advancing proteomic research and targeted protein degradation studies.
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