HSV-1/HSV-2-IN-3 is a potent inhibitor of the herpes simplex virus (HSV) helicase-primase complex, effectively disrupting the DNA unwinding and primer synthesis necessary for viral genome replication. It demonstrates an EC50 of 7.0 nM against HSV-2 in gD-immunofluorescence assays, and 1.1 nM in qPCR replication assays, highlighting its potent antiviral activity. Additionally, HSV-1/HSV-2-IN-3 exhibits high selectivity for viral targets, with an IC50 of approximately 2.9 µM for human carbonic anhydrase II, making it a valuable tool for anti-HSV research applications.
HSV-1/HSV-2-IN-3 is a potent inhibitor of the herpes simplex virus (HSV) helicase-primase complex, effectively disrupting the DNA unwinding and primer synthesis necessary for viral genome replication. It demonstrates an EC50 of 7.0 nM against HSV-2 in gD-immunofluorescence assays, and 1.1 nM in qPCR replication assays, highlighting its potent antiviral activity. Additionally, HSV-1/HSV-2-IN-3 exhibits high selectivity for viral targets, with an IC50 of approximately 2.9 µM for human carbonic anhydrase II, making it a valuable tool for anti-HSV research applications.
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