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HTH-01-015

NUAK1 inhibitor

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Catalog No. A16281

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
HTH-01-015 5mg A16281-5
$90.00
HTH-01-015 10mg A16281-10
$120.00
HTH-01-015 50mg A16281-50
$400.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members.

HTH-01-015

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Chemical Information

Catalog Num A16281
Actions Inhibitor
M. Wt 468.56
Formula C26H28N8O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1613724-42-7
Synonyms HTH01-015, HTH 01-015
SMILES code CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1
Chemical Name 4,5,13-trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one

Biological Activity

Description
HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members.
Targets
NUAK1 NUAK2
100 nM>10 μM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.34 mL 106.71 mL 213.42mL
0.5 mM 4.27 mL 21.34 mL 42.68 mL
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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