Fig. 1 · Structure
Documents & Downloads
HUHS2002
Cholinesterase (ChE)
HUHS2002 is a free fatty acid derivative that primarily targets cholinesterase (ChE) to enhance α7 nicotinic acetylcholine receptor activity. This compound significantly increases whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner, with effects reversibly blocked by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. Furthermore, HUHS2002 activates CaMKII in cultured rodent hippocampal neurons, an effect also inhibited by KN-93. Additionally, HUHS2002 exhibits partial inhibition of protein phosphatase 1 (PP1) activity in a cell-free assay, suggesting its potential use in studying cholinergic signaling pathways and neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1393102-59-4 |
| Applications | Cholinesterase (ChE) |
| Formula | C17H24O3 |
| Molecular Weight | 276.37 |
| SMILES | O=C(CCCOC1=CC=C(C=C1)/C=C/CCCCC)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.