HUP-55 is a potent prolyl endopeptidase inhibitor with an IC50 of 5 nM. This compound significantly reduces α-synuclein dimerization in Neuro2a cells and induces autophagy in HEK293 cells. Additionally, HUP-55 effectively decreases reactive oxygen species (ROS) production in SH-SY5Y cells when administered at 10 μM. In vivo studies reveal that HUP-55 enhances motor function and reduces harmful oligomer levels of α-synuclein in the striatum in a mouse model of Parkinson’s disease, demonstrating its potential in neuroprotective research applications.
HUP-55 is a potent prolyl endopeptidase inhibitor with an IC50 of 5 nM. This compound significantly reduces α-synuclein dimerization in Neuro2a cells and induces autophagy in HEK293 cells. Additionally, HUP-55 effectively decreases reactive oxygen species (ROS) production in SH-SY5Y cells when administered at 10 μM. In vivo studies reveal that HUP-55 enhances motor function and reduces harmful oligomer levels of α-synuclein in the striatum in a mouse model of Parkinson’s disease, demonstrating its potential in neuroprotective research applications.
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