IC-87114

Catalog No.: A10463

PI3K Inhibitor

IC-87114

IC-87114 Chemical Structure

CAS NO. 371242-69-2

IC-87114 was the first isoform-selective PI3K inhibitor :p110M-NM-4(IC50 = 0.13 M-BM-5M) vs. p110M-NM-1(IC50 = 200 M-BM-5M), p110M-NM-2(IC50 = 16 M-BM-5M) and p110M-NM-3(IC50 = 61 M-BM-5M).

Availability: In stock

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5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $80.00

Special Price $64.00

25 mg

Regular Price: $150.00

Special Price $120.00

100 mg

Regular Price: $400.00

Special Price $320.00

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Biological Activity

IC-87114 was the first isoform-selective PI3K inhibitor :p110M-NM-4(IC50 = 0.13 M-BM-5M) vs. p110M-NM-1(IC50 = 200 M-BM-5M), p110M-NM-2(IC50 = 16 M-BM-5M) and p110M-NM-3(IC50 = 61 M-BM-5M).
Targets
PI3Kδ (Cell-free assay) PI3Kγ (Cell-free assay) PI3Kβ (Cell-free assay)
0.5 μM29 μM75 μM
In vitro (25°C) DMSO 0.62 mg/mL (1.56 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 0.6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.82 mL 251.64 mL
0.5 mM 5.03 mL 25.16 mL 50.33 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10463
Actions Inhibitor
CAS No. 371242-69-2
Formula C22H19N7O
M. Wt 397.4
Purity >98%
SMILES CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C4N=CN=C5N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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