Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
Biological Activity
IC-87114 was the first isoform-selective PI3K inhibitor :p110M-NM-4(IC50 = 0.13 M-BM-5M) vs. p110M-NM-1(IC50 = 200 M-BM-5M), p110M-NM-2(IC50 = 16 M-BM-5M) and p110M-NM-3(IC50 = 61 M-BM-5M).
Targets
PI3Kδ (Cell-free assay) | PI3Kγ (Cell-free assay) | PI3Kβ (Cell-free assay) | ||
0.5 μM | 29 μM | 75 μM |
In vitro (25°C) | DMSO | 0.62 mg/mL (1.56 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+30% PEG 300+ddH2O | 0.6 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.16 mL | 125.82 mL | 251.64 mL |
0.5 mM | 5.03 mL | 25.16 mL | 50.33 mL |
1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
*The above data is based on the productmolecular weight 397.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10463 |
---|---|
Actions | Inhibitor |
CAS No. | 371242-69-2 |
Formula | C22H19N7O |
M. Wt | 397.4 |
Purity | >98% |
SMILES | CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C4N=CN=C5N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy IC-87114 | IC-87114 Supplier | purchase | cost | manufacturer | order | distributor | buy 371242-69-2| 371242-69-2 Supplier | purchase 371242-69-2 | 371242-69-2 cost | 371242-69-2 manufacturer | order 371242-69-2 | 371242-69-2 distributor