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Biological Activity
Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.67 mL | 38.33 mL | 76.66 mL |
| 0.5 mM | 1.53 mL | 7.67 mL | 15.33 mL |
| 1 mM | 0.77 mL | 3.83 mL | 7.67 mL |
| 5 mM | 0.15 mL | 0.77 mL | 1.53 mL |
*The above data is based on the productmolecular weight 1304.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18074 |
|---|---|
| Actions | Antagonist |
| CAS No. | 130308-48-4 |
| Formula | C59H89N19O13S |
| M. Wt | 1304.52 |
| Purity | >98% |
| Synonyms | Firazyr |
| SMILES | N=C(N)NC(C(C1NCC2=C(C=CC=C2)C1)=O)CC[C@@H](C(O)=O)N(C([C@H](CO)N(C(CN(C([C@H]3N(C([C@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)N)=O)=O)CCC3)=O)C(C4NC[C@H](O)C4)=O)=O)C([C@H](CC5=CC=CS5)N)=O)=O)C(C6N[C@@]7([H])CCCC[C@@]7([H])C6)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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