- Jasper C.Munro, .et al. Cardiac function and feed efficiency: increased right-heart workload in feed inefficient beef cattle, Livest Sci, 2019, 229 (2019) 159-169
- Kim JH, .et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus, Cell Rep, 2019, May 14;27(7):2105-2118.e5 PMID: 31091449
- Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
- Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536
Biological Activity
ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .
Targets
CBP (Cell-free assay) | ||||
3 μM |
In vitro (25°C) | DMSO | 99 mg/mL (180.45 mM) | |
Water | Insoluble | ||
Ethanol | 10 mg/mL | ||
In vivo | 2% DMSO+50% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.23 mL | 91.14 mL | 182.28 mL |
0.5 mM | 3.65 mL | 18.23 mL | 36.46 mL |
1 mM | 1.82 mL | 9.11 mL | 18.23 mL |
5 mM | 0.36 mL | 1.82 mL | 3.65 mL |
*The above data is based on the productmolecular weight 548.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11039 |
---|---|
Actions | Inhibitor |
CAS No. | 780757-88-2 |
Formula | C33H32N4O4 |
M. Wt | 548.6 |
Purity | >98% |
Synonyms | ICG001 |
SMILES | C1CN([[email protected]]2CN(C(=O)[[email protected]@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy ICG-001 | ICG-001 Supplier | purchase | cost | manufacturer | order | distributor | buy 780757-88-2| 780757-88-2 Supplier | purchase 780757-88-2 | 780757-88-2 cost | 780757-88-2 manufacturer | order 780757-88-2 | 780757-88-2 distributor