ICI-63197 is a dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), exhibiting Ki values of 9 µM and 10 µM, respectively. This compound demonstrates selectivity against PDE1 and PDE2, allowing for targeted modulation of cyclic nucleotide levels. ICI-63197 is noted for its antidepressant effects, making it a valuable tool for research into mood disorders and the underlying mechanisms of antidepressant action.
ICI-63197 is a dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), exhibiting Ki values of 9 µM and 10 µM, respectively. This compound demonstrates selectivity against PDE1 and PDE2, allowing for targeted modulation of cyclic nucleotide levels. ICI-63197 is noted for its antidepressant effects, making it a valuable tool for research into mood disorders and the underlying mechanisms of antidepressant action.
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