Icotinib

Catalog No.: A13825

EGFR inhibitor

Icotinib

Icotinib Chemical Structure

CAS NO. 610798-31-7

Icotinib is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).

Availability: In stock

Package Price Qty
5 mg
$180.00
10 mg
$260.00
25 mg
$480.00
50 mg
$780.00
10mM * 1mL in DMSO
$200.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Icotinib is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).
Targets
EGFR
5 nM
In vitro (25°C) DMSO 78 mg/mL (199.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (17.88 mM)
In vivo 0.5% CMC 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.55 mL 127.74 mL 255.48 mL
0.5 mM 5.11 mL 25.55 mL 51.1 mL
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL

*The above data is based on the productmolecular weight 391.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A13825
Actions Inhibitor
M. Wt 391.42
Formula C22H21N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 610798-31-7
Synonyms BPI-2009H
SMILES C#CC1=CC(=CC=C1)NC2=NC=NC3=CC4=C(C=C32)OCCOCCOCCO4

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