ID11916 is an orally active antagonist of the androgen receptor (AR) and a phosphodiesterase 5 (PDE5) inhibitor. It effectively inhibits androgen binding to AR, prevents nuclear translocation, and suppresses androgen-dependent transcriptional activity. Additionally, ID11916 elevates intracellular cGMP levels and activates protein kinase G (PKG) through its inhibitory effects. This compound demonstrates significant anti-cancer activity against prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell lines such as SK-BR-3, making it a valuable tool for cancer research.
ID11916 is an orally active antagonist of the androgen receptor (AR) and a phosphodiesterase 5 (PDE5) inhibitor. It effectively inhibits androgen binding to AR, prevents nuclear translocation, and suppresses androgen-dependent transcriptional activity. Additionally, ID11916 elevates intracellular cGMP levels and activates protein kinase G (PKG) through its inhibitory effects. This compound demonstrates significant anti-cancer activity against prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell lines such as SK-BR-3, making it a valuable tool for cancer research.
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