IDE397 (GSK-4362676) is a potent and selective inhibitor of methionine adenosyltransferase 2A (MAT2A). It exhibits strong anti-tumor activity, particularly in patient-derived xenograft (PDX) models with MTAP (methylthioadenosine phosphorylase) deletion. By targeting MAT2A in MTAP-deficient tumors, IDE397 exploits a synthetic lethality approach, making it a promising candidate for precision oncology research.
IDE397 (GSK-4362676) is a potent and selective inhibitor of methionine adenosyltransferase 2A (MAT2A). It exhibits strong anti-tumor activity, particularly in patient-derived xenograft (PDX) models with MTAP (methylthioadenosine phosphorylase) deletion. By targeting MAT2A in MTAP-deficient tumors, IDE397 exploits a synthetic lethality approach, making it a promising candidate for precision oncology research.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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