IDO1-IN-30 is a selective and potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), demonstrating an IC50 of 4.8 nM in SKOV3 cells. This compound exhibits minimal cytotoxicity in HepG2 cells at concentrations up to 25 µM and does not significantly inhibit CYP450 enzymes, including 3A4, 2C9, and 2D6. IDO1-IN-30 is suitable for studies focused on cancer immunotherapy and the modulation of inflammatory responses.
IDO1-IN-30 is a selective and potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), demonstrating an IC50 of 4.8 nM in SKOV3 cells. This compound exhibits minimal cytotoxicity in HepG2 cells at concentrations up to 25 µM and does not significantly inhibit CYP450 enzymes, including 3A4, 2C9, and 2D6. IDO1-IN-30 is suitable for studies focused on cancer immunotherapy and the modulation of inflammatory responses.
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