IDO1/TDO-IN-8 is a dual inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO) with the ability to penetrate the blood-brain barrier. It exhibits EC50 values of 0.33 μM for IDO1 and 1.78 μM for TDO, effectively reducing the kynurenine/tryptophan ratio by modulating the kynurenine pathway of tryptophan metabolism. This compound demonstrates neuroprotective properties, alleviating motor dysfunction and mitigating depressive symptoms, making it a valuable tool in the investigation of neurodegenerative disorders such as Parkinson's disease co-occurring with depression.
IDO1/TDO-IN-8 is a dual inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO) with the ability to penetrate the blood-brain barrier. It exhibits EC50 values of 0.33 μM for IDO1 and 1.78 μM for TDO, effectively reducing the kynurenine/tryptophan ratio by modulating the kynurenine pathway of tryptophan metabolism. This compound demonstrates neuroprotective properties, alleviating motor dysfunction and mitigating depressive symptoms, making it a valuable tool in the investigation of neurodegenerative disorders such as Parkinson's disease co-occurring with depression.
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