IDOR-1104-0086 is an orally active Kv7 channel opener, demonstrating an EC50 of 210 nM and the ability to cross the blood-brain barrier. This compound exhibits strong selectivity against the hERG channel, with an IC20 of 25 μM. IDOR-1104-0086 has shown efficacy in rodent models of epilepsy and possesses a favorable tolerability profile, making it a valuable tool for research in epilepsy and related neurological disorders.
IDOR-1104-0086 is an orally active Kv7 channel opener, demonstrating an EC50 of 210 nM and the ability to cross the blood-brain barrier. This compound exhibits strong selectivity against the hERG channel, with an IC20 of 25 μM. IDOR-1104-0086 has shown efficacy in rodent models of epilepsy and possesses a favorable tolerability profile, making it a valuable tool for research in epilepsy and related neurological disorders.
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